Glycine receptor antibodies are detected in progressive encephalomyelitis with rigidity and myoclonus (PERM) but not in saccadic oscillations.

Journal article

Glycine receptor (GlyR) antibodies were recently identified in a few patients with progressive encephalomyelitis with rigidity and myoclonus (PERM); none of these patients had antibodies against glutamic acid decarboxylase (GAD). An inhibitory glycinergic transmission defect has also been implicated in the mechanism underlying saccadic oscillations, including ocular flutter or opsoclonus; GlyR antibodies have not been reported in these patients. The purpose was to determine whether GlyR antib...

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Authors: Iizuka, T; Leite, M; Lang, B; Waters, P; Urano, Y

• Publication status: Published
• Journal: Journal of neurology
• Volume: 259
• Issue: 8
• Pages: 1566-1573
• Publication date: 2012-08-01
• DOI: 10.1007/s00415-011-6377-2
• EISSN: 1432-1459
• ISSN: 0340-5354
• Language: English
• Keywords: Humans; Ocular Motility Disorders; Saccades; Middle Aged; Myoclonus; Female; Encephalomyelitis; Male; Disease Progression; Muscle Rigidity; Autoantibodies; Receptors, Glycine; Adult