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Journal article

The improved lytic function and in vivo efficacy of monovalent monoclonal CD3 antibodies.

Abstract:

A series of hybrid-hybridomas were derived by the cell fusion of a CD3 antibody-secreting hybridoma with other Ig-producing cell lines. The Ig molecules secreted by these hybrid-hybridomas were fractionated by ion-exchange chromatography, and fractions containing monovalent CD3 antibodies were tested for complement-mediated lysis of T cells. Two monovalent CD3 antibodies with mixed heavy chain isotypes were very poor in lysis but, in contrast, a monovalent antibody possessing two identical ra...

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Publication status:
Published

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Publisher copy:
10.1002/eji.1830190224

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Journal:
European journal of immunology
Volume:
19
Issue:
2
Pages:
381-388
Publication date:
1989-02-05
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
URN:
uuid:f430541f-55f0-4155-bdd8-f7ea35701c2c
Source identifiers:
7961
Local pid:
pubs:7961

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