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DNA damage and nonhomologous end joining in excitotoxicity: neuroprotective role of DNA-PKcs in kainic acid-induced seizures.

Abstract:

DNA repair plays a critical, but imprecisely defined role in excitotoxic injury and neuronal survival throughout adulthood. We utilized an excitotoxic injury model to compare the location and phenotype of degenerating neurons in mice (strain 129-C57BL) deficient in the catalytic subunit of the DNA-dependent protein kinase (DNA-PKcs), an enzyme required for nonhomologous end joining (NHEJ). Brains from untreated adult heterozygous and DNA-PKcs null mice displayed comparable cytoarchitecture an...

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Publisher copy:
10.1002/hipo.20123

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Institution:
University of Oxford
Department:
Oxford, MSD, Experimental Psychology
Role:
Author
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Journal:
Hippocampus
Volume:
15
Issue:
8
Pages:
1057-1071
Publication date:
2005-01-01
DOI:
EISSN:
1098-1063
ISSN:
1050-9631
URN:
uuid:f427e168-55fe-4193-a60f-9b2d52ce03fc
Source identifiers:
374484
Local pid:
pubs:374484

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