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Journal article

Simian immunodeficiency virus-specific cytotoxic T lymphocytes and protection against challenge in rhesus macaques immunized with a live attenuated simian immunodeficiency virus vaccine.

Abstract:

In this study, we examined the role of simian immunodeficiency virus (SIV)-specific cytotoxic T lymphocytes (CTLs) in macaques immunized with an attenuated strain of simian immunodeficiency virus (SIVmac239Deltanef) in protection against pathogenic challenge with SIVmac251. Our results indicate that attenuated SIVmac239Deltanef can elicit specific CTL precursor cells (CTLp), but no correlation was observed between breadth or strength of CTLp response to structural proteins SIV-Env, -Gamg or -...

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Publication status:
Published

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Publisher copy:
10.1006/viro.1999.0078

Authors


Donahoe, SM More by this author
Kakimoto, WM More by this author
Samuel, RV More by this author
Metzner, KJ More by this author
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Journal:
Virology
Volume:
266
Issue:
1
Pages:
203-210
Publication date:
2000-01-05
DOI:
EISSN:
1096-0341
ISSN:
0042-6822
URN:
uuid:f4268bfb-999e-423c-9848-3aaa525fdc3a
Source identifiers:
67026
Local pid:
pubs:67026

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