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Hypoxia and mitochondrial inhibitors regulate expression of glucose transporter-1 via distinct Cis-acting sequences.

Abstract:

Studies of gene regulation by oxygen have recently defined the existence of a widely operative system that responds to hypoxia but not mitochondrial inhibitors and involves the induction of a DNA-binding complex termed hypoxia-inducible factor 1. This system has been implicated in the regulation of erythropoietin, certain angiogenic growth factors, and particular glycolytic isoenzymes. The glucose transporter Glut-1 is induced by both hypoxia and mitochondrial inhibitors, implying the operati...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.270.49.29083

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, CCMP, Biomedical Research Centre
Journal:
The Journal of biological chemistry
Volume:
270
Issue:
49
Pages:
29083-29089
Publication date:
1995-12-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:f423a961-df23-443c-b9be-63cf9dc6c033
Source identifiers:
29559
Local pid:
pubs:29559

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