Corticostriatal regulation of striatal dopamine (DA) transmission has long been postulated, but ionotropic glutamate receptors have not been localized directly to DA axons. Striatal cholinergic interneurons (ChIs) are emerging as major players in striatal function, and can govern DA transmission by activating nicotinic receptors (nAChRs) on DA axons. Cortical inputs to ChIs have historically been perceived as sparse, but recent evidence indicates that they strongly activate ChIs. We explo...Expand abstract
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- Cerebral Cortex Journal website
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© The Author 2016. Published by Oxford University Press.
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Cortical control of striatal dopamine transmission via striatal cholinergic interneurons
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