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Cortical control of striatal dopamine transmission via striatal cholinergic interneurons

Abstract:

Corticostriatal regulation of striatal dopamine (DA) transmission has long been postulated, but ionotropic glutamate receptors have not been localized directly to DA axons. Striatal cholinergic interneurons (ChIs) are emerging as major players in striatal function, and can govern DA transmission by activating nicotinic receptors (nAChRs) on DA axons. Cortical inputs to ChIs have historically been perceived as sparse, but recent evidence indicates that they strongly activate ChIs. We explo...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/cercor/bhw252

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Role:
Author
The Clarendon Fund More from this funder
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Grant:
J-0901 Monument Trust Discovery Award
Publisher:
Oxford University Press Publisher's website
Journal:
Cerebral Cortex Journal website
Volume:
26
Issue:
11
Pages:
4160–4169
Publication date:
2016-10-17
Acceptance date:
2016-07-19
DOI:
EISSN:
1460-2199
ISSN:
1047-3211
Source identifiers:
634669
Keywords:
Pubs id:
pubs:634669
UUID:
uuid:f41f8807-92a3-40fb-b539-0f7e51502f9d
Local pid:
pubs:634669
Deposit date:
2016-07-20

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