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Cortical control of striatal dopamine transmission via striatal cholinergic interneurons

Abstract:

Corticostriatal regulation of striatal dopamine (DA) transmission has long been postulated, but ionotropic glutamate receptors have not been localized directly to DA axons. Striatal cholinergic interneurons (ChIs) are emerging as major players in striatal function, and can govern DA transmission by activating nicotinic receptors (nAChRs) on DA axons. Cortical inputs to ChIs have historically been perceived as sparse, but recent evidence indicates that they strongly activate ChIs. We explo...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
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Publisher copy:
10.1093/cercor/bhw252

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oxford Parkinson’s Disease Centre
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oxford Parkinson’s Disease Centre
Role:
Author
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Publisher:
Oxford University Press (OUP) Publisher's website
Journal:
Cerebral Cortex Journal website
Volume:
26
Issue:
11
Pages:
4160–4169
Publication date:
2016-10-17
Acceptance date:
2016-07-19
DOI:
EISSN:
1460-2199
ISSN:
1047-3211
URN:
uuid:f41f8807-92a3-40fb-b539-0f7e51502f9d
Source identifiers:
634669
Local pid:
pubs:634669

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