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Regulation of clonal growth by anti-T-cell receptor antibody-directed lysis.

Abstract:

CD4 and CD8 T-cell clones were generated using the Mx9 monoclonal antibody (mAb), which recognizes the V beta 8 T-cell receptor (TcR) gene family. The interaction of these clones with the Mx9 antibody was analysed and all were found to be specifically stimulated to proliferate by plastic-adherent Mx9. In the presence of Mx9 or its F(ab')2 fragment, CD8+ Mx9+ clones were capable of specifically lysing the CD4+ Mx9+ T-cell clones. No lysis was seen of Mx9- T cells, or in the absence of the anti...

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Publication status:
Published

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Authors


De Berardinis, P More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Journal:
Immunology
Volume:
64
Issue:
3
Pages:
439-443
Publication date:
1988-07-05
EISSN:
1365-2567
ISSN:
0019-2805
URN:
uuid:f41ae43f-1244-4279-ada5-48aebccad261
Source identifiers:
481785
Local pid:
pubs:481785

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