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Cholinergic modulation of midbrain dopaminergic systems.

Abstract:

Dopamine neurons in the midbrain respond to behavioral events and environmental stimuli. Their different patterns of activation in turn modulate the activity of forebrain regions and modulate the expression of selective behavioral responses. However, their activity is closely dependent on the cholinergic systems in the brainstem. Ascending cholinergic projections from the pedunculopontine and laterodorsal tegmental nuclei target dopaminergic neurons in the substantia nigra compacta and ventra...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford
Role:
Author
Journal:
Brain research reviews
Volume:
58
Issue:
2
Pages:
265-271
Publication date:
2008-08-05
DOI:
EISSN:
1872-6321
ISSN:
0165-0173
URN:
uuid:f41ad53e-6eae-4593-ba6e-6b59505a4656
Source identifiers:
375293
Local pid:
pubs:375293

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