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The immunological synapse: integrins take the stage.

Abstract:

Adhesive interactions play important roles in coordinating T-cell migration and activation, specifically in the formation of the immunological synapse (IS), a specialized cell-cell junction. Recent demonstrations show several molecules implicated in T-cell signaling, including Vav, ADAP, and Rap-1, have major roles in integrin regulation and place adhesion molecules at center stage in addressing the question: what are the signals involved in the formation of the IS and full T-cell activation?...

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Journal:
Immunological reviews
Volume:
186
Issue:
1
Pages:
100-117
Publication date:
2002-08-05
DOI:
EISSN:
1600-065X
ISSN:
0105-2896
URN:
uuid:f419ec8c-95f7-4ebe-88dc-faf6d01a9e86
Source identifiers:
482647
Local pid:
pubs:482647

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