The immunological synapse: integrins take the stage.

Journal article

Adhesive interactions play important roles in coordinating T-cell migration and activation, specifically in the formation of the immunological synapse (IS), a specialized cell-cell junction. Recent demonstrations show several molecules implicated in T-cell signaling, including Vav, ADAP, and Rap-1, have major roles in integrin regulation and place adhesion molecules at center stage in addressing the question: what are the signals involved in the formation of the IS and full T-cell activation?...

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Authors: Sims, T; Dustin, M

• Journal: Immunological reviews
• Volume: 186
• Issue: 1
• Pages: 100-117
• Publication date: 2002-08-01
• DOI: 10.1034/j.1600-065x.2002.18610.x
• EISSN: 1600-065X
• ISSN: 0105-2896
• Language: English
• Keywords: Cell Adhesion; Cytoskeletal Proteins; Humans; Synapses; Cell Adhesion Molecules; Lymphocyte Activation; Signal Transduction; Lymphocyte Function-Associated Antigen-1; Receptors, Antigen, T-Cell; T-Lymphocytes; Integrins; Animals