The oncogenic LIM-only transcription factor Lmo2 regulates angiogenesis but not vasculogenesis in mice.

Journal article

The LMO2 gene is activated by chromosomal translocations in human T cell acute leukemias, but in mouse embryogenesis, Lmo2 is essential for initiation of yolk sac and definitive hematopoiesis. The LMO2 protein comprises two LIM-zinc-finger-like protein interaction modules and functions by interaction with specific partners in DNA-binding transcription complexes. We have now investigated the role of Lmo2-associated transcription complexes in the formation of the vascular system by following th...

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Authors: Yamada, Y; Pannell, R; Forster, A; Rabbitts, T

• Journal: Proceedings of the National Academy of Sciences of the United States of America
• Volume: 97
• Issue: 1
• Pages: 320-324
• Publication date: 2000-01-01
• DOI: 10.1073/pnas.97.1.320
• EISSN: 1091-6490
• ISSN: 0027-8424
• Language: English
• Keywords: Proto-Oncogene Proteins; Animals; Chimera; Adaptor Proteins, Signal Transducing; Embryonic and Fetal Development; Mice; Metalloproteins; DNA-Binding Proteins; Lac Operon; LIM Domain Proteins; In Situ Hybridization; Recombination, Genetic; Transcription Factors; beta-Galactosidase; Endothelium, Vascular; Neovascularization, Physiologic; Stem Cells