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Palmitoylation at Cys574 is essential for MT1-MMP to promote cell migration.

Abstract:

MT1-MMP is a type I transmembrane proteinase that promotes cell migration and invasion. Here, we report that MT1-MMP is palmitoylated at Cys574 in the cytoplasmic domain, and this lipid modification is critical for its promotion of cell migration and clathrin-mediated internalization. The palmitoylation-defective mutant (C574A) failed to promote cell migration and was not internalized through clathrin pathway like wild-type, but it was internalized through the caveolae pathway. Reintroducing ...

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Publication status:
Published

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Publisher copy:
10.1096/fj.04-3651fje

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
Journal:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology More from this journal
Volume:
19
Issue:
10
Pages:
1326-1328
Publication date:
2005-08-01
DOI:
EISSN:
1530-6860
ISSN:
0892-6638
Language:
English
Keywords:
Pubs id:
pubs:223915
UUID:
uuid:f4124f06-438e-4937-84af-44726f7ef052
Local pid:
pubs:223915
Source identifiers:
223915
Deposit date:
2012-12-19

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