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TGF-β limits IL-33 production and promotes the resolution of colitis through regulation of macrophage function.

Abstract:

Mϕs promote tissue injury or repair depending on their activation status and the local cytokine milieu. It remains unclear whether the immunosuppressive effects of transforming growth factor β (TGF-β) serve a nonredundant role in Mϕ function in vivo. We generated Mϕ-specific transgenic mice that express a truncated TGF-β receptor II under control of the CD68 promoter (CD68TGF-βDNRII) and subjected these mice to the dextran sodium sulfate (DSS) model of colitis. CD68TGF-βDNRII mice have an imp...

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Publication status:
Published

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Publisher copy:
10.1002/eji.201041135

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School, BHF Centre of Research Excellence
Role:
Author
Journal:
European journal of immunology
Volume:
41
Issue:
7
Pages:
2000-2009
Publication date:
2011-07-05
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
URN:
uuid:f411d589-6c73-411f-9558-8a28614cb81c
Source identifiers:
131233
Local pid:
pubs:131233

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