TGF-β limits IL-33 production and promotes the resolution of colitis through regulation of macrophage function.

Journal article

Mϕs promote tissue injury or repair depending on their activation status and the local cytokine milieu. It remains unclear whether the immunosuppressive effects of transforming growth factor β (TGF-β) serve a nonredundant role in Mϕ function in vivo. We generated Mϕ-specific transgenic mice that express a truncated TGF-β receptor II under control of the CD68 promoter (CD68TGF-βDNRII) and subjected these mice to the dextran sodium sulfate (DSS) model of colitis. CD68TGF-βDNRII mice have an imp...

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Authors: Rani, R; Smulian, A; Greaves, D; Hogan, S; Herbert, DR

• Publication status: Published
• Journal: European journal of immunology
• Volume: 41
• Issue: 7
• Pages: 2000-2009
• Publication date: 2011-07-01
• DOI: 10.1002/eji.201041135
• EISSN: 1521-4141
• ISSN: 0014-2980
• Language: English
• Keywords: Receptors, Transforming Growth Factor beta; Flow Cytometry; Dextran Sulfate; Mice; Transforming Growth Factor beta; Mice, Transgenic; Animals; Colitis, Ulcerative; Antigens, CD; Macrophages; Immunoglobulin E; Disease Models, Animal; Colitis; Antigens, Differentiation, Myelomonocytic; Promoter Regions, Genetic; Blotting, Southern; Interleukins