The effects of dieting and weight loss on neuroendocrine responses to tryptophan, clonidine, and apomorphine in volunteers. Important implications for neuroendocrine investigations in depression.

Journal article

The increases in the growth hormone (GH) level following intravenous infusion of the 5-hydroxytryptamine precursor tryptophan, the alpha 2-adrenoceptor agonist clonidine hydrochloride, and subcutaneous injection of the dopamine agonist apomorphine hydrochloride were determined in volunteers before and in the third week of a weight-reducing diet (1200 kcal/d). The increases in the prolactin level following intravenous infusion of tryptophan and in response to protirelin were also determined. I...

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Authors: Goodwin, G; Fairburn, C; Cowen, P

• Publication status: Published
• Journal: Archives of general psychiatry
• Volume: 44
• Issue: 11
• Pages: 952-957
• Publication date: 1987-11-01
• DOI: 10.1001/archpsyc.1987.01800230032007
• EISSN: 1538-3636
• ISSN: 0003-990X
• Language: English
• Keywords: Growth Hormone; Diet; Humans; Adult; Apomorphine; Male; Neurosecretory Systems; Female; Body Weight; Prolactin; Clonidine; Tryptophan