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Longitudinal mid-life stroke risk predicts brain structure in the aging whitehall II cohort

Abstract:

Background: Multi-measure cardiovascular and stroke risk scores predict gray matter volume reduction and white matter changes. We aimed to establish whether: 1) there is an association between Framingham stroke risk (FSRS) in mid-life across five phases (P) and reduced structural brain integrity beyond the effects of chronological or biological age, and 2) the predicted effects on brain structure reduction in older age are the same 5 (P9), 10 (P7), 15 (P5) and 22 (P3) yea...

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Publication status:
Published
Peer review status:
Reviewed (other)

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Publisher copy:
10.1016/j.biopsych.2019.03.543

Authors


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Institution:
University of Oxford
Department:
Psychiatry
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Psychiatry
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Psychiatry
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Psychiatry
Role:
Author
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Name:
European Commission
Grant:
732592
More from this funder
Name:
Medical Research Council
Grant:
G1001354
Publisher:
Elsevier
Host title:
Biological Psychiatry
Journal:
Biological Psychiatry More from this journal
Volume:
85
Issue:
10
Pages:
S215
Publication date:
2019-05-15
Acceptance date:
2019-04-15
DOI:
EISSN:
1873-2402
ISSN:
0006-3223
Language:
English
Keywords:
Pubs id:
pubs:1033290
UUID:
uuid:f404ad35-3c29-4680-a41f-8217c9ee9fbc
Local pid:
pubs:1033290
Source identifiers:
1033290
Deposit date:
2019-08-06

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