Assembly and function of the two ABC transporter proteins encoded in the human major histocompatibility complex.

Journal article

Presentation of cytoplasmic antigens to class I-restricted cytotoxic T cells implied the existence of a specialized peptide transporter. For most class I heavy chains, association with peptides of the appropriate length is required for stable assembly with beta 2-microglobulin. Mutant cells RMA-S and .174/T2 neither assemble stable class I molecules nor present intracellular antigens, and we have suggested that they have lost a function required for the transport of short peptides from the cy...

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Authors: Kelly, A; Powis, S; Kerr, L; Mockridge, I; Elliott, T

• Publication status: Published
• Journal: Nature
• Volume: 355
• Issue: 6361
• Pages: 641-644
• Publication date: 1992-02-01
• DOI: 10.1038/355641a0
• EISSN: 1476-4687
• ISSN: 0028-0836
• Language: English
• Keywords: Membrane Proteins; Molecular Sequence Data; Precipitin Tests; Histocompatibility Antigens Class I; Electrophoresis, Polyacrylamide Gel; Carrier Proteins; Gene Expression; ATP-Binding Cassette Transporters; Mutation; Transformation, Genetic; Base Sequence; Blotting, Southern; Protein Biosynthesis; Humans; Genotype; Amino Acid Sequence; Major Histocompatibility Complex