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The dielectric properties of water within model transbilayer pores

Abstract:

Ion channels contain extended columns of water molecules within their transbilayer pores. The dynamic properties of such intrapore water have been shown to differ from those of water in its bulk state. In previous molecular dynamics simulations of two classes of model pore (parallel bundles of Ala20 alpha-helices and antiparallel barrels of Ala10 beta-strands), a substantially reduced translational and rotational mobility of waters was observed within the pore relative to bulk water. Molecula...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/S0006-3495(97)78269-9

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Institution:
University of Oxford
Department:
Medical Sciences Division - Biochemistry
Role:
Author
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Funding agency for:
P.C. Biggin
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Publisher:
Elsevier Inc. Publisher's website
Journal:
Biophysical Journal Journal website
Volume:
73
Issue:
5
Pages:
2404–2415
Publication date:
1997-11-05
DOI:
ISSN:
0006-3495
URN:
uuid:f401eefa-40a6-45ca-8c13-7a1b4eb4b78b
Local pid:
ora:8110

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