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MS: a localized immune disease of the central nervous system.

Abstract:

The precise role of T cells in multiple sclerosis (MS) remains to be defined. No MS-specific antigen has been found. The autoimmune hypothesis for MS rests on immune changes seen in the spinal fluid and brain and on the demonstration, in an experimental animal model, that T cells raised to myelin basic protein transfer demyelination. In this review, Virginia Calder and colleagues focus on recent studies suggesting that in MS, the initial T-cell response occurs within the central nervous syste...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
Journal:
Immunology today
Volume:
10
Issue:
3
Pages:
99-103
Publication date:
1989-03-05
DOI:
ISSN:
0167-5699
URN:
uuid:f3ff93e0-eef7-4902-a59d-a2c566189221
Source identifiers:
481673
Local pid:
pubs:481673

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