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Initiation of T cell signaling by CD45 segregation at ‘close contacts’

Abstract:

It has been proposed that the local segregation of kinases and the tyrosine phosphatase CD45 underpins T cell antigen receptor (TCR) triggering, but how such segregation occurs and whether it can initiate signaling is unclear. Using structural and biophysical analysis, we show that the extracellular region of CD45 is rigid and extends beyond the distance spanned by TCR-ligand complexes, implying that sites of TCR-ligand engagement would sterically exclude CD45. We also show that the formation...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/ni.3392

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM - Investigative Medicine Division
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Biology
Role:
Author
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Funding agency for:
Davis, S
Grant:
098274/Z/12/Z
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Funding agency for:
Jones, E
Grant:
C375/A10976
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Funding agency for:
Gilbert, R
Grant:
090532/Z/09/Z
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Funding agency for:
Aricescu, A
Grant:
G0700232
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Funding agency for:
Davis, S
Grant:
098274/Z/12/Z
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Immunology Journal website
Publication date:
2016-01-01
Acceptance date:
2015-12-29
DOI:
EISSN:
1529-2916
ISSN:
1529-2908
Source identifiers:
610140
Pubs id:
pubs:610140
UUID:
uuid:f3fe8fb7-dad9-4b9b-9f35-08621d56cae7
Local pid:
pubs:610140
Deposit date:
2016-03-15

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