Journal article
Initiation of T cell signaling by CD45 segregation at ‘close contacts’
- Abstract:
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It has been proposed that the local segregation of kinases and the tyrosine phosphatase CD45 underpins T cell antigen receptor (TCR) triggering, but how such segregation occurs and whether it can initiate signaling is unclear. Using structural and biophysical analysis, we show that the extracellular region of CD45 is rigid and extends beyond the distance spanned by TCR-ligand complexes, implying that sites of TCR-ligand engagement would sterically exclude CD45. We also show that the formation...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Publisher copy:
- 10.1038/ni.3392
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Authors
Funding
Bibliographic Details
- Publisher:
- Nature Publishing Group Publisher's website
- Journal:
- Nature Immunology Journal website
- Publication date:
- 2016-01-01
- Acceptance date:
- 2015-12-29
- DOI:
- EISSN:
-
1529-2916
- ISSN:
-
1529-2908
- Source identifiers:
-
610140
Item Description
- Pubs id:
-
pubs:610140
- UUID:
-
uuid:f3fe8fb7-dad9-4b9b-9f35-08621d56cae7
- Local pid:
- pubs:610140
- Deposit date:
- 2016-03-15
Terms of use
- Copyright holder:
- Chang et al
- Copyright date:
- 2016
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