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Lysosomal dysfunction promotes cleavage and neurotoxicity of tau in vivo

Abstract:

Expansion of the lysosomal system, including cathepsin D upregulation, is an early and prominent finding in Alzheimer's disease brain. Cell culture studies, however, have provided differing perspectives on the lysosomal connection to Alzheimer's disease, including both protective and detrimental influences. We sought to clarify and molecularly define the connection in vivo in a genetically tractable model organism. Cathepsin D is upregulated with age in a Drosophila model of Alzheimer's disea...

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Authors


Khurana, V More by this author
Elson-Schwab, I More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine
Loewen, CA More by this author
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Journal:
PLoS Genetics
Volume:
6
Issue:
7
Pages:
1-11
Publication date:
2010-07-05
DOI:
EISSN:
1553-7404
ISSN:
1553-7390
URN:
uuid:f3f87449-1231-4929-a879-3080f4f98235
Source identifiers:
300806
Local pid:
pubs:300806
Language:
English

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