Journal article
A dynamic CD2 rich compartment at the outer edge of the immunological synapse boosts and integrates signals
- Abstract:
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The CD2–CD58 recognition system promotes adhesion and signaling and counters exhaustion in human T cells. We found that CD2 localized to the outer edge of the mature immunological synapse, with cellular or artificial APC, in a pattern we refer to as a ‘CD2 corolla’. The corolla captured engaged CD28, ICOS, CD226 and SLAM-F1 co-stimulators. The corolla amplified active phosphorylated Src-family kinases (pSFK), LAT and PLC-γ over T cell receptor (TCR) alone. CD2–CD58 interactions in the corolla...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Accepted manuscript, 479.9KB)
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- Publisher copy:
- 10.1038/s41590-020-0770-x
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Authors
Bibliographic Details
- Publisher:
- Nature Research Publisher's website
- Journal:
- Nature Immunology Journal website
- Volume:
- 21
- Pages:
- 1232-1243
- Publication date:
- 2020-09-14
- Acceptance date:
- 2020-07-28
- DOI:
- EISSN:
-
1529-2916
- ISSN:
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1529-2908
Item Description
- Language:
- English
- Keywords:
- Pubs id:
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1119246
- Local pid:
- pubs:1119246
- Deposit date:
- 2020-07-16
Terms of use
- Copyright holder:
- Springer Nature
- Copyright date:
- 2020
- Rights statement:
- Copyright © 2020, Springer Nature
- Notes:
- This is the accepted manuscript version of the article. The final version is available from Nature Research at https://doi.org/10.1038/s41590-020-0770-x. An author correction for this article is available online at: https://doi.org/10.1038/s41590-020-00825-w
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