Journal article icon

Journal article

A dynamic CD2 rich compartment at the outer edge of the immunological synapse boosts and integrates signals

Abstract:

The CD2–CD58 recognition system promotes adhesion and signaling and counters exhaustion in human T cells. We found that CD2 localized to the outer edge of the mature immunological synapse, with cellular or artificial APC, in a pattern we refer to as a ‘CD2 corolla’. The corolla captured engaged CD28, ICOS, CD226 and SLAM-F1 co-stimulators. The corolla amplified active phosphorylated Src-family kinases (pSFK), LAT and PLC-γ over T cell receptor (TCR) alone. CD2–CD58 interactions in the corolla...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1038/s41590-020-0770-x

Authors


Expand authors...
Publisher:
Nature Research Publisher's website
Journal:
Nature Immunology Journal website
Volume:
21
Pages:
1232-1243
Publication date:
2020-09-14
Acceptance date:
2020-07-28
DOI:
EISSN:
1529-2916
ISSN:
1529-2908
Language:
English
Keywords:
Pubs id:
1119246
Local pid:
pubs:1119246
Deposit date:
2020-07-16

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP