Journal article
Development of EpiRisk: an online clinical tool for estimating the risk of major congenital malformations in pregnant women treated for epilepsy
- Abstract:
- Antiepileptic drugs (AED s) are known to associate with an increased risk of major congenital malformations (MCM s) in children born to women who become pregnant while taking them. As the indications for AED s continue to diversify, novel AED s emerge, and polytherapy becomes more prevalent, the volume and complexity of the information relating to teratogenic risk can become unmanageable for the clinician. This in turn makes accurate education of pregnant women treated with AED s regarding the risk of MCM s challenging. To enable clinicians to provide better information regarding the potential teratogenic risk of AED s, we outline here the method we have employed to underpin a new system of real‐time risk analysis, “EpiRisk .” When launched, EpiRisk will offer a user‐friendly, online clinical tool, compatible with all modern Internet browsers, smart phones, and personal computers. Using the most current published data, as well as “real world” data from the UK and the Australian Pregnancy Registers, EpiRisk will enable clinicians to quickly and accurately assess the teratogenic risk of AED s in mono‐ and polytherapy. EpiRisk may thus provide a future‐proof central hub for empowering patients, clinicians, and registries by delivering evidence‐based information on the teratogenic risk of the AED s in pregnant women with epilepsy through an easily accessible platform.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 337.5KB, Terms of use)
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- Publisher copy:
- 10.1002/epi4.12109
Authors
- Publisher:
- Wiley
- Journal:
- Epilepsia Open More from this journal
- Volume:
- 3
- Issue:
- 2
- Pages:
- 281-285
- Place of publication:
- United States
- Publication date:
- 2018-03-22
- Acceptance date:
- 2018-02-18
- DOI:
- EISSN:
-
2470-9239
- Pmid:
-
29881808
- Language:
-
English
- Keywords:
- Pubs id:
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896721
- Local pid:
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pubs:896721
- Deposit date:
-
2020-07-04
- ARK identifier:
Terms of use
- Copyright holder:
- Jones, GD et al.
- Copyright date:
- 2018
- Rights statement:
- © 2018 The Authors. Epilepsia Open published by Wiley Periodicals Inc. on behalf of International League Against Epilepsy. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
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