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A transient translaminar GABAergic interneuron circuit connects thalamocortical recipient layers in neonatal somatosensory cortex

Abstract:

GABAergic activity is thought to influence developing neocortical sensory circuits. Yet the late postnatal maturation of local layer (L)4 circuits suggests alternate sources of GABAergic control in nascent thalamocortical networks. We show that a population of L5b, somatostatin (SST)-positive interneuron receives early thalamic synaptic input and, using laser-scanning photostimulation, identify an early transient circuit between these cells and L4 spiny stellates (SSNs) that disappears by the...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.neuron.2016.01.015

Authors


Marques-Smith, A More by this author
Lyngholm, D More by this author
Kaufman, A More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
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Funding agency for:
Stacey, JA
John Fell Fund More from this funder
Publisher:
Cell Press Publisher's website
Journal:
Neuron Journal website
Volume:
89
Issue:
3
Pages:
p536–549
Publication date:
2016-02-03
DOI:
EISSN:
1097-4199
ISSN:
0896-6273
URN:
uuid:f3dbaff4-5dfb-4d72-818b-3b998f81aa9b
Source identifiers:
581338
Local pid:
pubs:581338

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