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Journal article

Visualization of activated platelets by targeted magnetic resonance imaging utilizing conformation-specific antibodies against glycoprotein IIb/IIIa.

Abstract:

Ruptured atherosclerotic plaques, lined with activated platelets, constitute an attractive target for magnetic resonance imaging (MRI). This study evaluated whether microparticles of iron oxide (MPIO) targeting ligand-induced binding sites (LIBS) on the activated conformation of glycoprotein IIb/IIIa could be used to image platelets. MPIO (size: 1 microm) were conjugated to anti-LIBS or control single-chain antibody. Following guidewire injury to mouse femoral artery, platelet adhesion was pr...

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Publication status:
Published

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Publisher copy:
10.1159/000135660

Authors


von zur Muhlen, C More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Cardiovascular Medicine, BHF Centre of Research Excellence
McAteer, MA More by this author
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Journal:
Journal of vascular research
Volume:
46
Issue:
1
Pages:
6-14
Publication date:
2009
DOI:
EISSN:
1423-0135
ISSN:
1018-1172
URN:
uuid:f3d5c19e-50a4-4d37-98ee-142c935c71ad
Source identifiers:
105297
Local pid:
pubs:105297

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