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Journal article

Influence of genetic and environmental factors on the immunogenicity of Hib vaccine in Gambian twins.

Abstract:

The differences in incidence rates of Haemophilus influenzae type b disease and the variation in Hib conjugate vaccine efficacy achieved among different ethnic groups suggest genetic influences on the immune response to Hib vaccine. The serum anti-PRP antibody concentration of 43 monozygotic (MZ) and 147 dizygotic (DZ) twin pairs in the Gambia was measured using a standardised Hib ELISA. Intrapair correlations for MZ and DZ twin pairs were compared and heritability in antibody responses to Hi...

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Publication status:
Published

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Journal:
Vaccine
Volume:
24
Issue:
25
Pages:
5335-5340
Publication date:
2006-06-05
DOI:
EISSN:
1873-2518
ISSN:
0264-410X
URN:
uuid:f3d28bc6-b57c-4a58-a4c3-334c0e37f7d2
Source identifiers:
119450
Local pid:
pubs:119450

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