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Role of osteoprotegerin (OPG) in cancer.

Abstract:

OPG (osteoprotegerin), a secreted member of the TNF (tumour necrosis factor) receptor superfamily, has a variety of biological functions which include the regulation of bone turnover. OPG is a potent inhibitor of osteoclastic bone resorption and has been investigated as a potential therapeutic for the treatment of both osteoporosis and tumour-induced bone disease. Indeed, in murine models of cancer-induced bone disease, inhibition of osteoclastic activity by OPG was also associated with a red...

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Publication status:
Published

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Publisher copy:
10.1042/cs20050175

Authors


Shipman, CM More by this author
Journal:
Clinical science (London, England : 1979)
Volume:
110
Issue:
3
Pages:
279-291
Publication date:
2006-03-05
DOI:
EISSN:
1470-8736
ISSN:
0143-5221
URN:
uuid:f3cf3dfd-bc95-46a0-998b-19d501084757
Source identifiers:
384068
Local pid:
pubs:384068

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