A Drosophila ortholog of the human cylindromatosis tumor suppressor gene regulates triglyceride content and antibacterial defense.

Journal article

The cylindromatosis (CYLD) gene is mutated in human tumors of skin appendages. It encodes a deubiquitylating enzyme (CYLD) that is a negative regulator of the NF-kappaB and JNK signaling pathways, in vitro. However, the tissue-specific function and regulation of CYLD in vivo are poorly understood. We established a genetically tractable animal model to initiate a systematic investigation of these issues by characterizing an ortholog of CYLD in Drosophila. Drosophila CYLD is broadly expressed d...

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Authors: Tsichritzis, T; Gaentzsch, P; Kosmidis, S; Brown, A; Skoulakis, E

• Publication status: Published
• Journal: Development (Cambridge, England)
• Volume: 134
• Issue: 14
• Pages: 2605-2614
• Publication date: 2007-07-01
• DOI: 10.1242/dev.02859
• EISSN: 1477-9129
• ISSN: 0950-1991
• Language: English
• Keywords: Drosophila melanogaster; Cell Line; Ubiquitin; Mutation; Fat Body; Tumor Suppressor Proteins; Organ Specificity; Drosophila Proteins; Enterococcus faecalis; Homeostasis; Escherichia coli; Animals; Embryo, Nonmammalian; Triglycerides