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Is the vasculature a potential therapeutic target in arthritis?

Abstract:

The vasculature fulfils a gatekeeper role in cell recruitment, through expression of leukocyte activators and chemoattractants, as well as adhesion molecules. Endothelial cells also play a role in the growth of new blood vessels ('angiogenesis'), which are vital for efficient supply of oxygen and nutrients to tissue. It is therefore unsurprising that the endothelium contributes to the initiation and maintenance of pathologies such as rheumatoid arthritis (RA). The expansion of RA synovium nec...

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Publisher copy:
10.2174/157339706776876053

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
Journal:
Current Rheumatology Reviews More from this journal
Volume:
2
Issue:
2
Pages:
151-158
Publication date:
2006-05-01
DOI:
ISSN:
1573-3971
Pubs id:
pubs:227911
UUID:
uuid:f3c36f3f-0697-4bc7-9322-b25ce34d8e4e
Local pid:
pubs:227911
Source identifiers:
227911
Deposit date:
2013-11-16

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