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Is the vasculature a potential therapeutic target in arthritis?

Abstract:

The vasculature fulfils a gatekeeper role in cell recruitment, through expression of leukocyte activators and chemoattractants, as well as adhesion molecules. Endothelial cells also play a role in the growth of new blood vessels ('angiogenesis'), which are vital for efficient supply of oxygen and nutrients to tissue. It is therefore unsurprising that the endothelium contributes to the initiation and maintenance of pathologies such as rheumatoid arthritis (RA). The expansion of RA synovium nec...

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Publisher copy:
10.2174/157339706776876053

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Paleolog, EM More by this author
Journal:
Current Rheumatology Reviews
Volume:
2
Issue:
2
Pages:
151-158
Publication date:
2006-05-05
DOI:
ISSN:
1573-3971
URN:
uuid:f3c36f3f-0697-4bc7-9322-b25ce34d8e4e
Source identifiers:
227911
Local pid:
pubs:227911

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