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Structural basis for protein-protein interactions in the 14-3-3 protein family.

Abstract:

The seven members of the human 14-3-3 protein family regulate a diverse range of cell signaling pathways by formation of protein-protein complexes with signaling proteins that contain phosphorylated Ser/Thr residues within specific sequence motifs. Previously, crystal structures of three 14-3-3 isoforms (zeta, sigma, and tau) have been reported, with structural data for two isoforms deposited in the Protein Data Bank (zeta and sigma). In this study, we provide structural detail for five 14-3-...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.0605779103

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Journal:
Proceedings of the National Academy of Sciences of the United States of America More from this journal
Volume:
103
Issue:
46
Pages:
17237-17242
Publication date:
2006-11-01
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Language:
English
Keywords:
Pubs id:
pubs:59297
UUID:
uuid:f3bcf839-c20e-4bb2-9a81-3c3b40744e3c
Local pid:
pubs:59297
Source identifiers:
59297
Deposit date:
2012-12-19

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