Journal article
Structure of the bone morphogenetic protein receptor ALK2 and implications for fibrodysplasia ossificans progressiva
- Abstract:
- Background: Mutations in the ALK2 kinase cause extraskeletal bone formation. Results: We solved the structure of ALK2 in complex with the inhibitor FKBP12. Conclusion: Disease mutations break critical interactions that stabilize the inactive ALK2-FKBP12 complex leading to kinase activation. Significance: We offer an explanation for the effects of mutation and a structural template for the design of small molecule inhibitors. © 2012 by The American Society for Biochemistry and Molecular Biology, Inc.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 3.7MB, Terms of use)
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- Publisher copy:
- 10.1074/jbc.M112.365932
Authors
+ University of Oxford
More from this funder
- Funding agency for:
- Sanvitale, C
- Grant:
- FOP Research Fund
- Journal:
- Journal of Biological Chemistry More from this journal
- Volume:
- 287
- Issue:
- 44
- Pages:
- 36990-36998
- Publication date:
- 2012-10-26
- DOI:
- EISSN:
-
1083-351X
- ISSN:
-
0021-9258
- Pubs id:
-
pubs:359721
- UUID:
-
uuid:f3baf9ad-c9dd-4e8a-abcc-df9bce12be05
- Local pid:
-
pubs:359721
- Source identifiers:
-
359721
- Deposit date:
-
2013-11-16
- ARK identifier:
Terms of use
- Copyright holder:
- The American Society for Biochemistry and Molecular Biology, Inc
- Copyright date:
- 2012
- Notes:
- © 2012 by The American Society for Biochemistry and Molecular Biology, Inc. Made available via a Creative Commons Attribution Non-Commercial License
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