Cited2 controls left-right patterning and heart development through a Nodal-Pitx2c pathway.

Journal article

Malformations of the septum, outflow tract and aortic arch are the most common congenital cardiovascular defects and occur in mice lacking Cited2, a transcriptional coactivator of TFAP2. Here we show that Cited2(-/-) mice also develop laterality defects, including right isomerism, abnormal cardiac looping and hyposplenia, which are suppressed on a mixed genetic background. Cited2(-/-) mice lack expression of the Nodal target genes Pitx2c, Nodal and Ebaf in the left lateral plate mesoderm, whe...

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Authors: Bamforth, S; Bragança, J; Farthing, C; Schneider, J; Broadbent, C

• Publication status: Published
• Journal: Nature genetics
• Volume: 36
• Issue: 11
• Pages: 1189-1196
• Publication date: 2004-11-01
• DOI: 10.1038/ng1446
• EISSN: 1546-1718
• ISSN: 1061-4036
• Language: English
• Keywords: Repressor Proteins; Gene Expression; Transforming Growth Factor beta; Homeodomain Proteins; DNA-Binding Proteins; Body Patterning; Transcription Factors; Heart Defects, Congenital; Crosses, Genetic; Transcription Factor AP-2; Mice, Inbred C57BL; Nodal Protein; Trans-Activators; Nuclear Proteins; Animals; Organogenesis; Heart; Mice, Knockout; Mice