Journal article

Glycosylation of the primary binding pocket of a subtilisin protease causes a remarkable broadening in stereospecificity in peptide synthesis

Abstract:: Site-selective glycosylation at position 166 at the base of the primary specificity S1 pocket in the serine protease subtilisin Bacillus lentus (SBL) created glycoproteins that are capable of catalyzing the coupling reactions of not only L- amino acid esters but also D-amino acid esters to give the corresponding dipeptides in good yields as a result of greatly broadened substrate specificities that can be rationalized by the interaction of the glycans acting as chiral auxiliaries in stereochemically mismatched pairs.

Publication status:: Published

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APA Style

Matsumoto, K., Davis, B., & Jones, J. (2001). Glycosylation of the primary binding pocket of a subtilisin protease causes a remarkable broadening in stereospecificity in peptide synthesis. CHEMICAL COMMUNICATIONS, 10, 903–904.

MLA Style

Matsumoto, K, et al. “Glycosylation of the Primary Binding Pocket of a Subtilisin Protease Causes a Remarkable Broadening in Stereospecificity in Peptide Synthesis.” CHEMICAL COMMUNICATIONS, no. 10, 2001, pp. 903–04.

Chicago Style

Matsumoto, K, B Davis, and J Jones. 2001. “Glycosylation of the Primary Binding Pocket of a Subtilisin Protease Causes a Remarkable Broadening in Stereospecificity in Peptide Synthesis.” CHEMICAL COMMUNICATIONS, no. 10: 903–4.
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Publisher copy:: 10.1039/b010021h

Authors

+ Matsumoto, K More by this author

Role:: Author

+ Davis, B More by this author

Institution:: University of Oxford
Division:: MPLS
Department:: Chemistry
Sub department:: Organic Chemistry
Role:: Author

+ Jones, J More by this author

Role:: Author

Journal:: CHEMICAL COMMUNICATIONS More from this journal
Issue:: 10
Pages:: 903-904
Publication date:: 2001-01-01
DOI:: 10.1039/b010021h
EISSN:: 1364-548X
ISSN:: 1359-7345

Language:: English
Pubs id:: pubs:52091
UUID:: uuid:f3b2ffa8-d66b-4b7f-9d6b-9ef7cde674f2
Local pid:: pubs:52091
Source identifiers:: 52091
Deposit date:: 2012-12-19
ARK identifier:: ark:/29072/ora_f3b2ffa8d66b4b7f9d6b9ef7cde674f2

Terms of use

Copyright date:: 2001

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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