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Postponement of satiety by blockade of brain cholecystokinin (CCK-B) receptors.

Abstract:

Exogenous cholecystokinin (CCK) decreases food intake and causes satiety in animals and man. However, it has not been established that endogenous CCK causes satiety or whether the response is mediated by peripheral-type (CCK-A) or brain-type (CCK-B) receptors. The development of potent and selective antagonists for CCK-A (MK-329) and CCK-B (L-365,260) receptors now allows these issues to be addressed. The CCK-A antagonist MK-329 and the CCK-B antagonist L-365,260 increased food intake in part...

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Publication status:
Published

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Publisher copy:
10.1126/science.2781294

Authors


Dourish, CT More by this author
Rycroft, W More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Experimental Psychology
Journal:
Science (New York, N.Y.)
Volume:
245
Issue:
4925
Pages:
1509-1511
Publication date:
1989-09-05
DOI:
EISSN:
1095-9203
ISSN:
0036-8075
URN:
uuid:f3a5727c-25f5-48d3-bb8a-a0609216e2ae
Source identifiers:
30875
Local pid:
pubs:30875

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