T-T interactions in the induction of suppressor and helper T cells: analysis of membrane phenotype of precursor and amplifier cells.

Journal article

The Ly and Ia phenotypes of T lymphocytes involved in the in vitro generation of helper and suppressor cells were identified. The precursors of both cells are found in adult thymectomized spleen. Helper precursors are Ly-1+2-3-Ia-, while suppressor precursors are Ly-1-2+3+Ia-, although the suppressor effector is Ia+. In both cases a second 'amplifier' cell is required for differentiation of precursors to occur. This cell is found in anti-lymphocyte serum-treated spleen and has the phenotype Ly-1+2+3+Ia-.

Authors: Feldmann, M; Beverley, P; Woody, J; McKenzie, I

• Publication status: Published
• Journal: Journal of experimental medicine
• Volume: 145
• Issue: 4
• Pages: 793-801
• Publication date: 1977-04-01
• DOI: 10.1084/jem.145.4.793
• EISSN: 1540-9538
• ISSN: 0022-1007
• Language: English
• Keywords: Mice; Immunosuppression; Antilymphocyte Serum; Phenotype; Epitopes; Animals; Cell Membrane; Immunoglobulin M; T-Lymphocytes; Cell Differentiation; Spleen; Isoantigens