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Journal article

Impact of pre-adapted HIV transmission

Abstract:

Human leukocyte antigen class I (HLA)-restricted CD8(+) T lymphocyte (CTL) responses are crucial to HIV-1 control. Although HIV can evade these responses, the longer-term impact of viral escape mutants remains unclear, as these variants can also reduce intrinsic viral fitness. To address this, we here developed a metric to determine the degree of HIV adaptation to an HLA profile. We demonstrate that transmission of viruses that are pre-adapted to the HLA molecules expressed in the recipient i...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1038/nm.4100

Authors


More from this funder
Name:
Wellcome Trust
Funding agency for:
Goulder, P
Grant:
WT104748MA
More from this funder
Name:
Canadian Institutes of Health Research
Publisher:
Nature Publishing Group
Journal:
Nature medicine More from this journal
Volume:
22
Issue:
6
Pages:
606-613
Publication date:
2016-06-01
Acceptance date:
2016-04-07
DOI:
EISSN:
1546-170X
ISSN:
1078-8956
Language:
English
Keywords:
Pubs id:
pubs:623451
UUID:
uuid:f39ba95a-f90e-4f35-a35c-11eb4d7cedae
Local pid:
pubs:623451
Source identifiers:
623451
Deposit date:
2016-06-28

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