Journal article icon

Journal article

T-cell- and macrophage-mediated axon damage in the absence of a CNS-specific immune response: involvement of metalloproteinases.

Abstract:

Recent evidence has highlighted the fact that axon injury is an important component of multiple sclerosis pathology. The issue of whether a CNS antigen-specific immune response is required to produce axon injury remains unresolved. We investigated the extent and time course of axon injury in a rodent model of a delayed-type hypersensitivity (DTH) reaction directed against the mycobacterium bacille Calmette-Guérin (BCG). Using MRI, we determined whether the ongoing axon injury is restricted to...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1093/brain/124.11.2203

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
Journal:
Brain : a journal of neurology More from this journal
Volume:
124
Issue:
Pt 11
Pages:
2203-2214
Publication date:
2001-11-01
DOI:
EISSN:
1460-2156
ISSN:
0006-8950
Language:
English
Keywords:
Pubs id:
pubs:130839
UUID:
uuid:f39767ed-5c95-4a70-b30f-bd5b27cfc4f4
Local pid:
pubs:130839
Source identifiers:
130839
Deposit date:
2012-12-19

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP