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T-cell- and macrophage-mediated axon damage in the absence of a CNS-specific immune response: involvement of metalloproteinases.

Abstract:

Recent evidence has highlighted the fact that axon injury is an important component of multiple sclerosis pathology. The issue of whether a CNS antigen-specific immune response is required to produce axon injury remains unresolved. We investigated the extent and time course of axon injury in a rodent model of a delayed-type hypersensitivity (DTH) reaction directed against the mycobacterium bacille Calmette-Guérin (BCG). Using MRI, we determined whether the ongoing axon injury is restricted to...

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Publication status:
Published

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Publisher copy:
10.1093/brain/124.11.2203

Authors


Newman, TA More by this author
Woolley, ST More by this author
Hughes, PM More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
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Journal:
Brain : a journal of neurology
Volume:
124
Issue:
Pt 11
Pages:
2203-2214
Publication date:
2001-11-05
DOI:
EISSN:
1460-2156
ISSN:
0006-8950
URN:
uuid:f39767ed-5c95-4a70-b30f-bd5b27cfc4f4
Source identifiers:
130839
Local pid:
pubs:130839

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