Acute myeloid leukaemia blast cells with a tyrosine kinase domain mutation of FLT3 are less sensitive to lestaurtinib than those with a FLT3 internal tandem duplication.

Journal article

FLT3 tyrosine kinase domain mutations (FLT3/TKDs) are associated with a favourable prognosis in acute myeloid leukaemia (AML), unlike FLT3 internal tandem duplications (FLT3/ITDs) that have a poor prognosis. Whilst FLT3/ITD+ cells are more susceptible to the cytotoxic effects of FLT3 inhibitors than wild type (WT) cells, the sensitivity of FLT3/TKD+ cells to therapeutic agents is unclear, as is the importance of the mutant level. We therefore studied the effect of cytarabine and the FLT3 inhi...

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Authors: Mead, A; Gale, R; Kottaridis, P; Matsuda, S; Khwaja, A

• Journal: British journal of haematology
• Volume: 141
• Issue: 4
• Pages: 454-460
• Publication date: 2008-05-01
• DOI: 10.1111/j.1365-2141.2008.07025.x
• EISSN: 1365-2141
• ISSN: 0007-1048
• Language: English
• Keywords: Adolescent; Protein-Tyrosine Kinases; Male; Dose-Response Relationship, Drug; Aged; Carbazoles; Adult; Cytarabine; Drug Screening Assays, Antitumor; Leukemia, Myeloid, Acute; Neoplastic Stem Cells; Mutation; Middle Aged; fms-Like Tyrosine Kinase 3; Protein Kinase Inhibitors; Antineoplastic Agents; Female; Humans; Tandem Repeat Sequences; Antineoplastic Combined Chemotherapy Protocols