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Functional consequences of a polymorphism affecting NF-kappaB p50-p50 binding to the TNF promoter region.

Abstract:

Stimulation of the NF-kappaB pathway often causes p65-p50 and p50-p50 dimers to be simultaneously present in the cell nucleus. A natural polymorphism at nucleotide -863 in the human TNF promoter (encoding tumor necrosis factor [TNF]) region provides an opportunity to dissect the functional interaction of p65-p50 and p50-p50 at a single NF-kappaB binding site. We found that this site normally binds both p65-p50 and p50-p50, but a single base change specifically inhibits p50-p50 binding. Report...

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Publication status:
Published

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Authors


Udalova, IA More by this author
Richardson, A More by this author
Ackerman, H More by this author
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Journal:
Molecular and cellular biology
Volume:
20
Issue:
24
Pages:
9113-9119
Publication date:
2000-12-05
DOI:
EISSN:
1098-5549
ISSN:
0270-7306
URN:
uuid:f3957aae-bb7f-40ea-861b-1dbbd70a6e0e
Source identifiers:
226867
Local pid:
pubs:226867

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