Extracortical origin of some murine subplate cell populations.

Journal article

The subplate layer, the deepest cortical layer in mammals, has important roles in cerebral cortical development. The subplate contains heterogeneous cell populations that are morphologically diverse, with several projection targets. It is currently assumed that these cells are generated in the germinative zone of the earliest cortical neuroepithelium. Here we identify a pallial but extracortical area located in the rostromedial telencephalic wall (RMTW) that gives rise to several cell populations. Postmitotic neurons migrate tangentially from the RMTW toward the cerebral cortex. Most RMTW-derived cells are incorporated into the subplate layer throughout its rostrocaudal extension, with others contributing to the GABAergic interneuron pool of cortical layers V and VI.

Authors: Pedraza, M; Hoerder-Suabedissen, A; Albert-Maestro, M; Molnár, Z; De Carlos, J

• Publication status: Published
• Publisher: National Academy of Sciences
• Journal: Proceedings of the National Academy of Sciences of the United States of America
• Volume: 111
• Issue: 23
• Pages: 8613-8618
• Publication date: 2014-06-01
• DOI: 10.1073/pnas.1323816111
• EISSN: 1091-6490
• ISSN: 0027-8424
• Language: English
• Keywords: Embryo, Mammalian; gamma-Aminobutyric Acid; Mice, Transgenic; Cerebral Cortex; Microscopy, Fluorescence; Interneurons; Mice, Inbred C57BL; Neurons; Time Factors; Animals; Green Fluorescent Proteins; GABAergic Neurons; Microscopy, Confocal; Cell Movement; Mice