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The prolyl hydroxylase enzymes are positively associated with hypoxia-inducible factor-1α and vascular endothelial growth factor in human breast cancer and alter in response to primary systemic treatment with epirubicin and tamoxifen.

Abstract:

INTRODUCTION: The purpose of the present study was to investigate the relationship of expression of hypoxia inducible factor (HIF)-1α-modifying enzymes prolyl hydroxylase (PHD)1, PHD2 and PHD3 to response of tumours and survival in breast cancer patients enrolled in a phase II trial of neoadjuvant anthracycline and tamoxifen therapy. METHODS: The expression of PHD1, PHD2 and PHD3 together with HIF-1α and the HIF-inducible genes vascular endothelial cell growth factor (VEGF) and carbonic anhyd...

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Publication status:
Published

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Publisher copy:
10.1186/bcr2825

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Journal:
Breast cancer research : BCR More from this journal
Volume:
13
Issue:
1
Pages:
R16
Publication date:
2011-01-01
DOI:
EISSN:
1465-542X
ISSN:
1465-5411

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