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The mechanism of HIV-1 core assembly: insights from three-dimensional reconstructions of authentic virions.

Abstract:

Infectious HIV particles contain a characteristic cone-shaped core encasing the viral RNA and replication proteins. The core exhibits significant heterogeneity in size and shape, yet consistently forms a well-defined structure. The mechanism by which the core is assembled in the maturing virion remains poorly understood. Using cryo-electron tomography, we have produced three-dimensional reconstructions of authentic, unstained HIV-1. These reveal the viral morphology with unprecedented clarity...

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Publisher copy:
10.1016/j.str.2005.09.010

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Journal:
Structure (London, England : 1993)
Volume:
14
Issue:
1
Pages:
15-20
Publication date:
2006-01-05
DOI:
EISSN:
1878-4186
ISSN:
0969-2126
URN:
uuid:f3904d49-4afd-4426-aef7-8fb68c41d041
Source identifiers:
66461
Local pid:
pubs:66461

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