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A genome-wide association study of diabetic kidney disease in subjects with type 2 diabetes

Abstract:

Identification of sequence variants robustly associated with predisposition to diabetic kidney disease (DKD) has the potential to provide insights into the pathophysiological mechanisms responsible. We conducted a genome-wide association study (GWAS) of DKD in type 2 diabetes (T2D) using eight complementary dichotomous and quantitative DKD phenotypes: the principal dichotomous analysis involved 5,717 T2D subjects, 3,345 with DKD. Promising association signals were evaluated in up to 26,827...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.2337/db17-0914

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Human Genetics Wt Centre
Role:
Author
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Role:
Author
ORCID:
0000-0003-4322-6942
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; OCDEM
Role:
Author
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Seventh Framework Program More from this funder
Academy of Finland More from this funder
Agency for Science and Technology and Research of Singapore More from this funder
Albert Påhlsson Foundation More from this funder
Alexandra Health More from this funder
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Publisher:
American Diabetes Association Publisher's website
Journal:
Diabetes Journal website
Volume:
67
Issue:
7
Pages:
1414-1427
Publication date:
2018-04-27
Acceptance date:
2018-03-29
DOI:
EISSN:
1939-327X
ISSN:
0012-1797
Pmid:
29703844
Source identifiers:
568311
Language:
English
Keywords:
Pubs id:
pubs:568311
UUID:
uuid:f3860d36-645b-4890-aee3-a8d256ea1146
Local pid:
pubs:568311
Deposit date:
2018-06-01

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