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A genome-wide association study of diabetic kidney disease in subjects with type 2 diabetes

Abstract:

Identification of sequence variants robustly associated with predisposition to diabetic kidney disease (DKD) has the potential to provide insights into the pathophysiological mechanisms responsible. We conducted a genome-wide association study (GWAS) of DKD in type 2 diabetes (T2D) using eight complementary dichotomous and quantitative DKD phenotypes: the principal dichotomous analysis involved 5,717 T2D subjects, 3,345 with DKD. Promising association signals were evaluated in up to 26,827...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.2337/db17-0914

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Human Genetics Wt Centre
Ahlqvist, E More by this author
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ORCID:
0000-0003-4322-6942
Deshmukh, H More by this author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; OCDEM
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Seventh Framework Program More from this funder
Academy of Finland More from this funder
Agency for Science and Technology and Research of Singapore More from this funder
Albert Påhlsson Foundation More from this funder
Alexandra Health More from this funder
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Publisher:
American Diabetes Association Publisher's website
Journal:
Diabetes Journal website
Volume:
67
Issue:
7
Pages:
1414-1427
Publication date:
2018-04-27
Acceptance date:
2018-03-29
DOI:
EISSN:
1939-327X
ISSN:
0012-1797
Pubs id:
pubs:568311
URN:
uri:f3860d36-645b-4890-aee3-a8d256ea1146
UUID:
uuid:f3860d36-645b-4890-aee3-a8d256ea1146
Local pid:
pubs:568311

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