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Parkinson's disease in a dish - Using stem cells as a molecular tool

Abstract:

Parkinson's disease (PD) is the second most common neurodegenerative disease, with a strong genetic component to both the familial and sporadic forms. The cardinal motor symptoms of the disease result from the loss of dopamine (DA) neurons in the midbrain. There is currently no cure for PD and improved methods for modelling the disease are required in order to develop more effective therapeutic interventions. Patient-derived induced pluripotent stem cells (iPSCs) carry the genetic background ...

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Publisher copy:
10.1016/j.neuropharm.2013.08.035
Journal:
Neuropharmacology More from this journal
Volume:
76
Issue:
PART A
Pages:
88-96
Publication date:
2014-01-01
DOI:
EISSN:
1873-7064
ISSN:
0028-3908
Pubs id:
pubs:438751
UUID:
uuid:f37988e4-1989-4174-ba53-ab012b58c1b1
Local pid:
pubs:438751
Source identifiers:
438751
Deposit date:
2013-12-13

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