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Competitive recruitment of the periplasmic translocation portal TolB by a natively disordered domain of colicin E9.

Abstract:

The natively disordered N-terminal 83-aa translocation (T) domain of E group nuclease colicins recruits OmpF to a colicin-receptor complex in the outer membrane (OM) as well as TolB in the periplasm of Escherichia coli, the latter triggering translocation of the toxin across the OM. We have identified the 16-residue TolB binding epitope in the natively disordered T-domain of the nuclease colicin E9 (ColE9) and solved the crystal structure of the complex. ColE9 folds into a distorted hairpin w...

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Publisher copy:
10.1073/pnas.0603433103

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Journal:
Proceedings of the National Academy of Sciences of the United States of America More from this journal
Volume:
103
Issue:
33
Pages:
12353-12358
Publication date:
2006-08-01
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Language:
English
Keywords:
Pubs id:
pubs:310197
UUID:
uuid:f3765f2f-15a8-4f17-b0f4-9087b86ef152
Local pid:
pubs:310197
Source identifiers:
310197
Deposit date:
2013-11-16

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