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Evolution of growth hormone neurosecretory disturbance after cranial irradiation for childhood brain tumours: a prospective study.

Abstract:

To determine the aetiopathology of post-irradiation growth hormone (GH) deficiency, we performed a mixed longitudinal analysis of 56 24 h serum GH concentration profiles and 45 paired insulin-induced hypoglycaemia tests (ITT) in 35 prepubertal children, aged 1.5-11.8 years, with brain tumours in the posterior fossa (n = 25) or cerebral hemispheres (n = 10). Assessments were made before (n = 16), 1 year (n = 25) and 2 to 5 years (n = 15) after a cranial irradiation (DXR) dose of at least 30 Gy...

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Publication status:
Published

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Publisher copy:
10.1677/joe.0.1500329

Authors


Spoudeas, HA More by this author
Hindmarsh, PC More by this author
Matthews, DR More by this author
Journal:
The Journal of endocrinology
Volume:
150
Issue:
2
Pages:
329-342
Publication date:
1996-08-05
DOI:
EISSN:
1479-6805
ISSN:
0022-0795
URN:
uuid:f36abca1-eef3-4c46-af13-34a9edcadd4c
Source identifiers:
72960
Local pid:
pubs:72960

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