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Human MAIT and CD8αα cells develop from a pool of type-17 precommitted CD8+ T cells.

Abstract:

Human mucosal associated invariant T (MAIT) CD8(+) and Tc17 cells are important tissue-homing cell populations, characterized by high expression of CD161 ((++)) and type-17 differentiation, but their origins and relationships remain poorly defined. By transcriptional and functional analyses, we demonstrate that a pool of polyclonal, precommitted type-17 CD161(++)CD8αβ(+) T cells exist in cord blood, from which a prominent MAIT cell (TCR Vα7.2(+)) population emerges post-natally. During this e...

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Publication status:
Published

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Journal:
Blood
Volume:
119
Issue:
2
Pages:
422-433
Publication date:
2012-01-05
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:f36a29c8-80d0-443c-9de3-1f0813173b71
Source identifiers:
205973
Local pid:
pubs:205973

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