Stromal SPARC expression and patient survival after chemoradiation for non-resectable pancreatic adenocarcinoma.

Journal article

PURPOSE: Pancreatic stellate cells (PSC) drive desmoplasia in pancreatic cancer. Our study analyzed both tumor and PSC, since interaction of these cell types may promote tumor progression. RESULTS: SPARC was expressed predominantly in the peritumoral and distal stroma. SPARC in distal stroma correlated inversely with overall survival of the patients with LAPC (p = 0.013) with a relative hazard of 2.23 (95% CI, 1.05 to 4.72; p = 0.036). TGFbeta1 in the tumor was also a negative prognostic fact...

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Authors: Mantoni, T; Schendel, R; Rödel, F; Niedobitek, G; Al-Assar, O

• Publication status: Published
• Journal: Cancer biology and therapy
• Volume: 7
• Issue: 11
• Pages: 1806-1815
• Publication date: 2008-11-01
• DOI: 10.4161/cbt.7.11.6846
• EISSN: 1555-8576
• ISSN: 1538-4047
• Language: English
• Keywords: Gene Expression Profiling; Immunophenotyping; Proto-Oncogene Proteins c-akt; Osteonectin; Coculture Techniques; Biopsy; Time Factors; Disease Progression; Immunohistochemistry; Prognosis; Cohort Studies; Adenocarcinoma; Pancreatic Neoplasms; Humans; Transforming Growth Factor beta1