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Journal article

Applications of RNA interference high-throughput screening technology in cancer biology and virology.

Abstract:
RNA interference (RNAi) is an ancient intra-cellular mechanism that regulates gene expression and cell function. Large-scale gene silencing using RNAi high-throughput screening (HTS) has opened an exciting frontier to systematically study gene function in mammalian cells. This approach enables researchers to identify gene function in a given biological context and will provide considerable novel insight. Here, we review RNAi HTS strategies and applications using case studies in cancer biology and virology.
Publication status:
Published

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Publisher copy:
10.1007/s13238-014-0076-6

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Oxford Ludwig Institute
Role:
Author
Journal:
Protein and cell More from this journal
Volume:
5
Issue:
11
Pages:
805-815
Publication date:
2014-11-01
DOI:
EISSN:
1674-8018
ISSN:
1674-800X
Language:
English
Keywords:
Pubs id:
pubs:470974
UUID:
uuid:f34c27d6-dc59-4e2f-a297-7f0a28970068
Local pid:
pubs:470974
Source identifiers:
470974
Deposit date:
2014-07-11

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