Journal article

Igf2 ligand dependency of Pten +- developmental and tumour phenotypes in the mouse

Abstract:: The tumour suppressor PTEN is a key negative regulator of the PI3K-Akt pathway, and is frequently either reduced or lost in human tumours. Murine genetic studies have confirmed that reduction of Pten promotes tumourigenesis in multiple organs, and demonstrated dependency of tumour development on the activation of downstream components such as Akt. Insulin-like growth factors (IGFs) act via IGF1R to activate the PI3K-Akt pathway, and are commonly upregulated in cancer. A context-dependent inte...
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APA Style

Church, D., Phillips, B., Stuckey, D., Barnes, D., Buffa, F., Manek, S., Clarke, K., Harris, A., Carter, E., & Hassan, A. B. (2012). Igf2 ligand dependency of Pten +- developmental and tumour phenotypes in the mouse. Oncogene, 31(31), 3635–3646.

MLA Style

Church, D., et al. “Igf2 Ligand Dependency of Pten +- Developmental and Tumour Phenotypes in the Mouse.” Oncogene, vol. 31, no. 31, 2012, pp. 3635–46.

Chicago Style

Church, D, B Phillips, D Stuckey, D Barnes, F Buffa, S Manek, K Clarke, A Harris, E Carter, and AB Hassan. 2012. “Igf2 Ligand Dependency of Pten +- Developmental and Tumour Phenotypes in the Mouse.” Oncogene 31 (31): 3635–46.
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Publisher copy:: 10.1038/onc.2011.526

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+ Church, D More by this author

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+ Phillips, B More by this author

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+ Stuckey, D More by this author

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+ Barnes, D More by this author

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+ Buffa, F More by this author

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Bibliographic Details

Journal:: Oncogene More from this journal
Volume:: 31
Issue:: 31
Pages:: 3635-3646
Publication date:: 2012-08-02
DOI:: 10.1038/onc.2011.526
EISSN:: 1476-5594
ISSN:: 0950-9232

Item Description

Language:: English
Keywords:: IGF2

placenta

imprinting

PTEN

mammary gland

Cowden syndrome
Pubs id:: pubs:252404
UUID:: uuid:f34ba3b8-bde0-4564-af5f-535d94f1432e
Local pid:: pubs:252404
Source identifiers:: 252404
Deposit date:: 2012-12-19

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Copyright date:: 2012

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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