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Engineering and characterization of a fluorescent native-like HIV-1 envelope glycoprotein trimer

Abstract:

Generation of a stable, soluble mimic of the HIV-1 envelope glycoprotein (Env) trimer on the virion surface has been considered an important first step for developing a successful HIV-1 vaccine. Recently, a soluble native-like Env trimer (BG505 SOSIP.664) has been described. This protein has facilitated major advances in the HIV-1 vaccine field, since it was the first Env immunogen that induced consistent neutralizing antibodies against a neutralization-resistant (tier 2) virus. Moreover, BG5...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version)

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Publisher copy:
10.3390/biom5042919

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Sliepen, K More by this author
van Montfort, T More by this author
Ozorowski, G More by this author
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International AIDS Vaccine Initiative More from this funder
The Bill and Melinda Gates Foundation More from this funder
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Grant:
HHSN27201100016C
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Grant:
CHAVI-ID UM1 AI100663
Publisher:
MDPI Publisher's website
Journal:
Biomolecules Journal website
Volume:
5
Issue:
4
Pages:
2919-2934
Publication date:
2015
DOI:
ISSN:
2218-273X
URN:
uuid:f32f0eaf-6ec4-4e32-b17f-14c8763d6d69
Source identifiers:
604529
Local pid:
pubs:604529

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