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The NH2-terminal domain of rat CD2 binds rat CD48 with a low affinity and binding does not require glycosylation of CD2.

Abstract:

CD2, CD48 and CD58 are structurally similar cell adhesion-molecules forming a subset of the immunoglobulin superfamily (IgSF). In humans CD58 is a ligand for CD2 while in mice CD2 binds CD48. We constructed a soluble chimeric molecule comprising the extracellular portion of rat CD48 and domains 3 and 4 of rat CD4 (sCD48-CD4) and used it to examine whether CD2 is a ligand for CD48 in rats. sCD48-CD4-coated polystyrene Dynabeads formed rosettes on rat CD2-transfected COS-7 cells, and this roset...

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Publication status:
Published

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Publisher copy:
10.1002/eji.1830230628

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
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Journal:
European journal of immunology
Volume:
23
Issue:
6
Pages:
1373-1377
Publication date:
1993-06-05
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
URN:
uuid:f3279190-c584-4cce-825d-167170603b61
Source identifiers:
26053
Local pid:
pubs:26053

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